The pharmacological effect and use of the drug Lopid

Dosage Form

capsules, tablets, coated tablets

Pharmachologic effect

Lipid-lowering agents. Fibric acid derivative.

lopid

lopid

It reduces the concentration of drug in blood triglycerides, total cholesterol, LDL and VLDL. The main mechanism of action is: the activation of lipoprotein lipase. The drug inhibits the peripheral lipolysis; increases the excretion from the liver of free fatty acids; It reduces the synthesis of triglycerides in the liver. Lopid reduces inclusion of long chain fatty acids; accelerates the removal of cholesterol from the liver; increases the excretion of cholesterol. Lopid inhibits synthesis of VLDL and increases ground clearance. Lopid increases the formation of HDL, have anti-atherogenic effect.

Onset of action — 2-5 days, the maximum therapeutic effect develops after 4 weeks.

Contraindications

Severe liver disease (including primary biliary cirrhosis), cholelithiasis, chronic cholecystitis, severe renal failure, pregnancy, lactation, concomitant use of lovastatin, Hypersensitivity to Lopid.

Important:

During treatment, it is necessary to systematically monitor blood lipids. If the 3-month course of treatment has not led to a decrease in the lipid content in the blood, the drug should be discontinued.

Side effects

From the nervous system: dizziness, headache, extreme tiredness, fainting, paresthesia, drowsiness, depression.

From the digestive system: dry mouth, decreased appetite, heartburn, nausea, vomiting, gastralgia, abdominal pain, bloating, diarrhea or constipation, hyperbilirubinemia, increased activity of «liver» transaminases and alkaline phosphatase, cholelithiasis.

From the musculoskeletal system: myasthenia, myalgia, arthralgia, rhabdomyolysis.

From the side of hematopoiesis: leukopenia, anemia, bone marrow hypoplasia.

With the genitourinary system: loss of potency and / or libido.

Allergic reactions: skin rash, dermatitis.

Other: hypokalemia, alopecia, impaired vision, synovitis.

Application and dosage

The drug is administered in an amount of 600 milli grams per 30 minutes before a meal. Tablets can be washed down with a little water. You must take the medicine two times a day. The maximum daily dose is 1.5 grams.

The course of treatment can last up to several months. If there is evidence it can be repeated. For complete information, seek help from a specialist.

If you missed taking the drug, it is not necessary to increase the regular dose.

Overdose

Data on overdose of drugs does not exist.