Prinivil is used to treat high blood pressure (hypertension), congestive heart failure, and to improve survival after a heart attack.
Active substance ofÂ Prinivil
The nosological classification (ICD-10) ofÂ Prinivil
I10 Essential (primary) hypertension
I15 Secondary hypertension
I50.0 Congestive heart failure
Structure and Composition
1 tablet containing 5, 10 or 20 mg of lisinopril; per pack 28 pcs.
Prinivil. Indications: Essential and renovascular hypertension, congestive heart failure (in combination with digitalis and / or diuretics). Contraindications: Hypersensitivity, children’s age.
Pharmachologic effect ofÂ Prinivil
Mode of action — hypotensive.
Inhibits ACE, reduces the content of angiotensin II in the plasma reduces the excretion of aldosterone.
Side effects ofÂ Prinivil
Angioedema face, lips, limbs, tongue, throat, dizziness, headache, confusion, weakness, fatigue, cough, orthostatic effects (including hypotension), tachycardia, myocardial infarction, dyspeptic disorders, hepatitis, jaundice, urticaria, oliguria, uremia , kidney failure, impotence, and others.
Cardio vascular system: decrease in blood pressure, arrhythmias, chest pain, rarely — orthostatic hypotension, tachycardia.
From the nervous system: dizziness, headache, fatigue, drowsiness, muscle twitching limbs and lips, rarely — fatigue, mood lability, confusion.
From the digestive system: nausea, indigestion, loss of appetite, change in taste, abdominal pain, diarrhea, dry mouth.
From the side of hematopoiesis: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, anemia (a decrease of Hb, erythropenia).
Allergic reactions: angioedema, skin rash, pruritus.
Laboratory indicators: hyperkalemia, hyperuricemia; rarely — increased activity of «liver» transaminases, hyperbilirubinemia.
Other: «dry» cough, decreased potency; rarely — acute renal failure, arthralgia, myalgia, fever, swelling (tongue, lips, limbs), violation of fetal kidney.
Interaction ofÂ Prinivil
Indomethacin reduces the hypotensive effect. In a joint application with diuretics may potentiate hypotension. It slows the excretion of lithium from the body. While the use of potassium-sparing diuretics and potassium supplements can hyperkalemia.
Contraindications ofÂ Prinivil
Hypersensitivity to lizinoprilu or others. ACE inhibitors, pregnancy, lactation. Angioedema in history against the background of ACE inhibitor therapy, hereditary or idiopathic angioedema, aortic stenosis, cerebrovascular diseases (including cerebrovascular insufficiency), ischemic heart disease, coronary insufficiency, severe systemic autoimmune connective tissue disease (including SLE , scleroderma), inhibition of bone marrow hematopoiesis, diabetes mellitus, hyperkalaemia, bilateral renal artery stenosis, stenosis of the artery only kidney condition after kidney transplantation, renal failure, a diet with restriction of Na +, state, accompanied by a decrease in the bcc (including diarrhea, vomiting ), advanced age, the age of 18 years (safety and efficacy have not been studied)