Persantine is a platelet inhibitor prescribed to prevent thromboembolic complications after cardiac valve replacement.
Angioprotectors and proofreaders microcirculation
Pharmachologic effect of Persantine
The drug dilates the coronary vessels (mostly arterioles) and causes a significant increase in the volume of blood flow velocity.
Persantine increases the oxygen content in the venous blood of the coronary sinus and its uptake by the myocardium.
The drug contributes to the development of collateral coronary circulation, reduction of systemic vascular resistance, improves microcirculation, renders angioprotective action.
The substance is an antagonist of endogenous ADP agreganty it inhibits PDE prostacyclin synthesis increases PgI2, that inhibits platelet aggregation.
The drug reduces platelet adhesiveness, preventing the formation of clots in blood vessels and reduces blood flow to the ischemic focus. Antiplatelet effect occurs when the plasma concentration of 0.1 ug / ml.
The drug normalizes venous outflow, reduces the incidence of deep vein thrombosis in the postoperative period; It improves the microcirculation in the retina, glomerulus; It lowers the tone of cerebral vessels to be effective in dynamic cerebral circulatory disorders.
In obstetric practice: the main agent corrects the placental blood flow, prevents degenerative changes in the placenta (the threat of pre-eclampsia), eliminates tissue hypoxia fruit and contributes to the accumulation of glycogen.
Dipyridamole (trademarked as Persantine) is a medication that inhibits blood clot formation when given chronically and causes blood vessel dilation when given at high doses over a short time.
Indications for use
Thrombosis and thromboembolism (prevention of arterial and venous blood clots, including after operation prosthetic heart valves), prevention of stent occlusion and aortocoronary bypass grafts (in combination with ASA); heart failure; myocardial infarction; prevention of myocardial hypertrophy.
Treatment and prevention of disorders of cerebral circulation on ischemic type; encephalopathy.
Prevention of placental insufficiency in complicated pregnancy.
Microcirculatory disorders of any origin (composed of combination therapy), chronic lower limbs obliterating vascular disease, especially if you have risk factors (hypertension, smoking).
Treatment and prevention of influenza and SARS.
Treatment and prevention of DIC in children with infectious toxicosis and sepsis, three-component treatment of glomerulonephritis (complex therapy), suppression of platelet syndrome in children.
Carrying dipyridamole-thallium-201 perfusion scintigraphy with physical activity, dimiridamolovy stress echocardiography.
Contraindications of Persantine
Hypersensitivity, acute myocardial infarction, commonly sclerotic coronary atherosclerosis, unstable angina, GOKMP, decompensated chronic heart failure, arterial hypotension, severe arterial hypertension, severe arrhythmia, hemorrhagic diathesis, peptic ulcer and 12 duodenal ulcer (bleeding tendency), COPD, chronic renal failure , hepatic nedostatochnost.C caution. Lactation, children’s age (up to 12 years — lack of experience).
Side effects of Persantine
From the CCC: palpitations, tachycardia, bradycardia, «tides» of blood to the face, coronary steal syndrome (at doses greater than 225 mg / day), decreased blood pressure (especially with the rapid on / in the introduction).
From the digestive system: nausea, vomiting, diarrhea, epigastric pain.
From the blood and hemostasis system: thrombocytopenia, changes in the functional properties of platelets, bleeding, increased bleeding.
Other: weakness, dizziness, feeling of fullness of the ear ringing in the head, headache, facial flushing, arthritis, myalgia, rhinitis, and allergic reactions.