Lotensin: Uses and Dosage

Lotensin used to treat hypertension.

Structure and Composition

1. Tablets, film-coated.

1 tablet: benazepril hydrochloride 5 mg

Lotensin - patient information, description, dosage

Lotensin — patient information, description, dosage

Ingredients: Anhydrous colloidal silica (Aerosil 200), microcrystalline cellulose (Avicel PH 102), hydrogenated castor oil, lactose monohydrate, corn starch, crospovidone, hydroxypropyl methylcellulose, iron oxide yellow, iron oxide red, titanium dioxide, polyethylene glycol 8000, talc.

14 pcs. — Packaging calendar (1) — packs cardboard.

14 pcs. — Packaging calendar (2) — packs cardboard.

2. Tablets, film-coated.

1 tablet: benazepril hydrochloride 20 mg

Lotensin 20 mg

Lotensin 20 mg

Ingredients: Anhydrous colloidal silica (Aerosil 200), microcrystalline cellulose (Avicel PH 102), hydrogenated castor oil, lactose monohydrate, corn starch, crospovidone, hydroxypropyl methylcellulose, iron oxide yellow, iron oxide red, titanium dioxide, polyethylene glycol 8000, talc.

14 pcs. — Packaging calendar (1) — packs cardboard.

14 pcs. — Packaging calendar (2) — packs cardboard.

3. Tablets, film-coated

1 tablet: benazepril hydrochloride, 10 mg

Ingredients: Anhydrous colloidal silica (Aerosil 200), microcrystalline cellulose (Avicel PH 102), hydrogenated castor oil, lactose monohydrate, corn starch, crospovidone, hydroxypropyl methylcellulose, iron oxide yellow, titanium dioxide, polyethylene glycol 8000, talc.

Lotensin 10 mg

Lotensin 10 mg

14 pcs. — Packaging calendar (1) — packs cardboard.

14 pcs. — Packaging calendar (2) — packs cardboard.

4. Tablets, film-coated

1 tablet contains: benazepril hydrochloride, 5 mg or 20 mg

Excipients: Colloidal anhydrous silica (Aerosil 200), microcrystalline cellulose (Avicel PH 102), hydrogenated castor oil, lactose monohydrate, corn starch, crospovidone, hydroxypropyl methylcellulose, iron oxide yellow, iron red oxide, titanium dioxide, polyethylene glycol 8000, talc.

14 pcs. — Packaging calendar (1) — packs cardboard.

14 pcs. — Packaging calendar (2) — packs cardboard.

After a single dose: anti-hypertensive effect observed after 1 hour; It reaches a maximum effect within 2-4 hours; drug effect lasts up to 24 hours.

The systematic use of: a persistent reduction in blood pressure observed after 1 week.

Hypotensive effect: does not depend on age, race, and baseline plasma renin activity. With the sudden cancellation of the drug a sharp rise in blood pressure is observed.

Dosage

When hypertension:

The recommended starting dose for patients is 10 mg 1 time / day. The dose may be increased to 20 mg / day. The dose is adjusted depending on the dynamics of blood pressure (normally at intervals of 1-2 weeks). The total daily dose may be divided into two equal reception. The maximum daily dose (in hypertensive patients) is 40 mg in 1 or in 2 hours.

Side effects

In general, Lotensin well tolerated. Adverse effects arising during reception characteristic Lotensin and other ACE inhibitors are listed below.

Since the cardiovascular system: often — heartbeat, orthostatic hypotension; rarely — symptomatic hypotension, chest pain, angina pectoris, arrhythmias; very rarely — myocardial infarction.

On the part of the digestive tract: often — dyspeptic symptoms; rarely — diarrhea, constipation, nausea, vomiting, abdominal pain; very rarely — pancreatitis.

On the part of the liver and biliary tract: rarely — hepatitis (predominantly cholestatic), cholestatic jaundice.

Dermatological reactions: often — a rash, flushing, itching, photosensitivity; rarely — pemphigus; very rarely — Stevens-Johnson syndrome.

From the urinary system: often — frequent urination; rarely — increased levels of urea nitrogen and serum creatinine; very rarely — renal dysfunction.

The respiratory system: often — a non-productive cough, which can lead to irritation of the pharynx and larynx and hoarseness.

From the central and peripheral nervous system: often — headache, dizziness, fatigue; rarely — drowsiness, insomnia, increased nervous irritability.

From hemopoiesis system: very rarely — hemolytic anemia, thrombocytopenia.

From the sensory organs: rarely — ringing in the ears, impaired sense of taste.

Allergic reactions: seldom — angioedema, swelling of the lips and / or persons.

From the musculoskeletal system: rarely — arthralgia, arthritis, myalgia.

From the laboratory parameters: fewer than 0.1% of patients with essential hypertension treated with monotherapy Lotensin, as well as in the treatment of other ACE inhibitors, there was a slight increase in the levels of urea nitrogen and serum creatinine, eliminated after stopping treatment. Increasing these rates is more likely in patients with renal artery stenosis are also receiving diuretics.

Indications for use

— arterial hypertension;

— Chronic heart failure (in combination therapy).

Contraindications

— Angioedema with ACE inhibitor therapy in history;

— Pregnancy;

— Lactation (breastfeeding);

— Hypersensitivity to benasepril and other ingredients.