Lisinopril: Release form, Composition, Dosage, Side effects

Release form, composition and packing

1.Tablets are pink, round, flat with bevelled edges, with Valium on one party.

1 tab.

lisinopril (as dihydrate) 10 mg

Lisinopril 10 Mg.

Lisinopril 10 Mg.

Excipients: lactose monohydrate — 70 mg maize starch — 49 mg Povidone — 6 mg, methylene chloride — 0.55 mg talc — 3.13 mg magnesium stearate — 1.3 mg dye azorubin — 0.02 mg.

2. Tablets are dark orange, round, flat with bevelled edges, with Valium on one party.

1 tab.

lisinopril (as dihydrate) 2.5 mg

Excipients: lactose monohydrate — 77.5 mg corn starch — 49 mg, povidone — 6 mg, methylene chloride — 0.55 mg talc — 3.13 mg of magnesium stearate — 1.3 mg dye sunset yellow — 0.02 mg.

3. Tablets white or almost white, round, flat with bevelled edges, with Valium on one party.

1 tab.

lisinopril (as dihydrate) 20 mg

Excipients: lactose monohydrate — 65 mg maize starch — 49 mg Povidone — 6 mg, methylene chloride — 0.55 mg talc — 3.13 mg magnesium stearate — 1.3 mg Titanium dioxide — 0.02 mg.

4. Tablets are orange, round, flat with bevelled edges, with Valium on one party.

1 tab.

lisinopril (as dihydrate) 5 mg

Excipients: lactose monohydrate — 75 mg, corn starch — 49 mg, povidone — 6 mg, methylene chloride — 0.55 mg talc — 3.13 mg of magnesium stearate — 1.3 mg dye sunset yellow — 0.02 mg.

Indications for use

— Essential and renovascular hypertension (alone or in combination with other antihypertensive agents);

— Chronic heart failure (in combination therapy);

— Early treatment of acute myocardial infarction in combination therapy (in the first 24 hours with stable hemodynamics to maintain these indicators and prevention of left ventricular dysfunction and heart failure);

— Diabetic nephropathy (reduction of albuminuria in patients with type 1 diabetes with normal blood pressure and patients with type 2 diabetes with hypertension).

Contraindications

— Hypersensitivity, other ACE inhibitors, and drug components;

— Angioedema in history, including during treatment with ACE inhibitors;

— Hereditary angioedema or idiopathic angioedema edema;

— Pregnancy;

— Lactation;

— The age of 18 years (effectiveness and safety have been established);

— Lactose intolerance, lactase deficiency, glucose-galactose malabsorption.

Precautions: aortic stenosis, hypertrophic obstructive cardiomyopathy, bilateral renal artery stenosis, stenosis of the artery only kidney condition after kidney transplantation, severe renal insufficiency (creatinine clearance less than 30 ml / min.), hypotension, inhibition of bone marrow hematopoiesis, hypovolemic state (including diarrhea, vomiting), systemic connective tissue disease (including systemic lupus erythematosus, scleroderma), diabetes mellitus, CHD , cerebrovascular disease (including cerebrovascular insufficiency), severe chronic heart failure.

Dosage

Inside, 1 time / day in the morning without food, preferably in one and the same time.

Essential hypertension: an initial dose — 10 mg / day maintenance dose — 20 mg / day, maximum daily dose — 40 mg.

Renovascular hypertension or other conditions with increased activity of the RAAS: the initial dose — 2.5-5 mg / day. Need to monitor blood pressure, kidney function, potassium blood serum.

Chronic heart failure (together with diuretics and / or cardiac glycosides): initial dose — 2.5 mg / day. The gradual increase of 2.5 mg every 3-5 days. The maximum daily dose — 20 mg.

Diabetic nephropathy: an initial dose — 10 mg / day, which was increased to 20 mg / day as needed.

Overdose

Symptoms: marked reduction of blood pressure, dryness of the oral mucosa, drowsiness, urinary retention, constipation, fluid and electrolyte balance, renal failure, shortness of breath, tachycardia, palpitations, bradycardia, dizziness, anxiety, irritability.

Care should be taken:

during exercise, hot weather

There is a risk of development of dehydration and excessive reduction of blood pressure due to a decrease in blood volume

Side effects

The most common side effects: dizziness, headache, fatigue, diarrhea, dry cough, nausea.

Cardio — vascular system: marked reduction of blood pressure, chest pain, orthostatic hypotension, tachycardia, Brad and the car of the day, the emergence or worsening symptoms of heart failure, violation of atrioventricular conduction, myocardial infarction, palpitations.

On the part of the central nervous system: emotional lability, impaired concentration, somnolence, jerking of the limbs and lips, fatigue, asthenic syndrome, confusion.

From the side of hematopoiesis: leukopenia, neutropenia, agranulocytosis, thrombocytopenia, and anemia (decrease in the concentration of hemoglobin, hematocrit).

The respiratory system: dyspnea, dry cough, bronchospasm.

From the digestive system: dryness of the oral mucosa, anorexia, dyspepsia, changes in taste, abdominal pain, pancreatitis, jaundice (hepatocellular or cholestatic), hepatitis.

For the skin: increased sweating, alopecia, photosensitivity, pruritus.

With the genitourinary system: renal failure, oliguria, anuria, acute renal failure, uremia, proteinuria, reduced potency.

Allergic reactions: angioneurotic edema of the face, extremities, lips, tongue, epiglottis and / or throat, skin rash, hives, fever, positive test results antinuclear antibodies, increased erythrocyte sedimentation rate, eosinophilia, leukocytosis, intestinal angioedema.

Other: myalgia, arthralgia / arthritis, vasculitis.