Lanoxin (Digoxin)

Drug Information: Indications, Side Effects, Warnings

Category:  Cardiovascular Diseases

Group affiliation:

Cardiac-cardiac glycoside

Structure and Composition: Each tablet with a notch (code Wellcome HZA) contains 0.25 mg digoxin BF.

Indications lanoxin 0.25mg: Lanoxin is indicated for the treatment of congestive heart failure, especially in combination with atrial fibrillation; certain supraventricular arrhythmias.Lanoxin 40mg pills

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Description of the active substance (INN):

Dosage Form:

Pharmacological actionCardiac glycosides

  • Blocking transport Na + / K + -ATPase
  • Increases the content of Na + in cardiomyocytes
  • Opens Ca2 + -channels and Ca2 + entry into cardiac myocytes
  • Excess Na + results in faster release of Ca2 + from the sarcoplasmic reticulum
  • Increasing the concentration of Ca2 + leads to inhibition of troponin complex has an inhibitory effect on the interaction of actin and myosin
  • Systole becomes shorter and energy cost
  • Increased CRM and IOC
  • Reduces the CSR and MLC heart
  • Increases the tone of the myocardium
  • Reduce the size of infarction

Reduces myocardial oxygen demand



  • The drug used in the complex therapy of CHF FC II-IV (in the presence of clinical manifestations);
  • Tachysystolic form of flicker and flutter and paroxysmal chronic course (especially in combination with the CHF).

Side effects:

Digitalis intoxication:

  1. from CCC — ventricular paroxysmal tachycardia, ventricular premature beats (often politopnye or bigeminy), a nodal tachycardia, sinus bradycardia, SA blockade fibrilloflutter, AV block. From the digestive system: loss of appetite, nausea, vomiting, diarrhea, abdominal pain, bowel necrosis.
  2. From the senses: coloring visible objects in the yellow-green color, flashing «flies» in front of the eyes, blurred vision, perception of objects in a reduced or enlarged.
  3. Nervous system: insomnia, headache, dizziness, neuritis, sciatica, manic-depressive syndrome, paresthesia. From the side of hematopoiesis and hemostasis system: thrombocytopenic purpura, epistaxis, petechiae. Other: hypokalemia, gynecomastia, and allergic reactions.
  4. Treatment: removal of cardiac glycosides, the introduction of antidotes (unitiol, EDTA, anti-digoxin), symptomatic therapy.
  5. The dose of Lanoxin selected individually for each patient according to age, body weight and renal function.

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