Provera: Instructions for use and application in oncology

Provera improves condition of women whose menstrual periods have stopped or in case of an abnormal bleeding of uterus due to hormone imbalance.

Active substance of Provera


Excipients: corn starch; magnesium stearate; MCC; gelatin; polyethylene glycol 400; sodium starch glycolate; sodium docusate (85%) sodium benzoate (15%)

Pharmacological groups of Provera

Estrogens, progestins; antagonists, and their homologs

Antineoplastic hormonal and hormone antagonists

The nosological classification (ICD-10)

C50 Malignant neoplasm of breast

C54.1 Malignant neoplasm of the endometrium

C64 Malignant neoplasm of kidney, except renal pelvis



The drug forms of Provera

Tablets 100 mg: white, round, flat scored.

Tablets 500 mg: white, oblong, biconvex.

Indications for use Provera

Hormone-dependent breast cancer forms in postmenopausal women recurrent cancer (palliative treatment), recurrent and / or metastatic cancer of the endometrium, kidney (additional and / or palliative treatment).

Contraindications of Provera

Hypersensitivity, pregnancy.

Side effects

From the nervous system and sensory organs: dizziness, headache, nervousness, sleep disorders, drowsiness, weakness, depression.

Cardio-vascular system and blood (blood, hemostasis): thrombosis, thrombophlebitis.

Allergic reactions: rash, urticaria; in some cases — anaphylactoid reactions.

Other: nausea, breast tenderness, galactorrhea, increased body temperature, Cushing’s syndrome (chronic administration of high doses).

Dosing and Administration

Inside, in recurrent breast cancer in postmenopausal women at 400-1200 mg / day in patients with recurrent endometrial cancer and kidney — at 200-600 mg / day.

For use in oncology: additional and palliative treatment of recurrent and metastatic endometrial cancer or kidney cancer; palliative treatment of hormone-dependent forms of breast cancer in women of recurrent cancer in post-menopausal; prostate carcinoma, certain forms of BPH; cancer cachexia in advanced tumors of various localization.