Gleevec (Imatinib) — gleevec cost

Drug Information: Indications, Side Effects, Warnings

Category:  Cancer

Generic Gleevec interferes with the growth of some cancer cells; is used to treat certain types of leukemia (blood cancer), bone marrow disorders, and skin cancer, or certain tumors of the stomach and digestive system.

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Antineoplastic agent — a protein tyrosine kinase inhibitor [Antineoplastic — protein kinase inhibitors]Gleevec 100mg

Nosological classification (ICD-10):

C26 Malignant neoplasm of other and ill-defined digestive organs
C44.9 Malignant neoplasm of skin of unspecified region
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
C79.2 Secondary malignant neoplasm of skin
C91 Lymphoid leukemia [lymphocytic leukemia]
C91.0 Acute lymphoblastic leukemia
C92.1 Chronic myeloid leukemia
C96.2 Malignant mast cell tumor
D46 Myelodysplastic Syndromes
D47.1 Chronic myeloproliferative disease
D72.1 Eosinophilia


Capsules 100 mg, 1 capsule Active ingredient: 50 mg of imatinib; 100 mg
(corresponding to 119.50 mg or 59.75 mg of imatinib mesylate)

Excipients: MCC — 46 mg / 92 mg; crospovidone 7.5 mg / 15 mg; Colloidal silicon dioxide 1 mg / 2 mg; Magnesium stearate 0 75 mg / 1.5 mg; titanium dioxide 0.38 mg / 0.6 mg; gelatin 47.51 mg / 74.81 mg; dye yellow iron oxide 0.11 mg / 0.03 mg; iron oxide red dye (for caps. 100 mg) — 0.56 mg

The composition of the ink: dye iron oxide red (E172); shellac; soy lecithin


Description of the dosage form:

Capsules, 50 mg: opaque, size №3, light yellow or orange-yellow, marked «NVR SH» red ink.

Capsules 100 mg: opaque, size №1, orange or orange with a grayish tint, labeled «NVR SI» red ink.

Contents of capsules: powder white and yellow.


Characteristics of the product:

Anticancer agent, an inhibitor of protein tyrosine kinase.


— Imatinib has a selective inhibitory effect on the enzyme Vcr-Abl-tyrosine

— This enzyme forming the fusion gene region Bcr (breakpoint cluster region) and proto-Abl (Abelson)
— Effect on the cellular level is
— The drug selectively inhibits proliferation and induces apoptosis in cell lines expressing Vcr-Abl-tyrosine (including immature leukemic cells)
— Imatinib selectively inhibits WASH-Abl-positive colonies (derived from blood cells of patients with chronic myeloid leukemia)
— Imatinib inhibits proliferation and induces apoptosis in gastrointestinal stromal tumor (expressing a mutant tyrosine kinase c-Kit receptor).



After oral administration, the bioavailability of the drug is 98% on average. The coefficient of variation for the index AUC is 40-60%.

Distribution of matter:

About 95% of the imatinib binds to plasma proteins (mainly — with albumin and alpha-acid glycoprotein, to a minor extent — lipoproteins).

Metabolism: Imatinib is metabolized primarily in the liver (with the formation of the main metabolite (N-demethylated derivative piperazinovooe) circulating in the bloodstream).

Indications for use:

— Newly diagnosed Philadelphia chromosome positive (Ph +) chronic myeloid leukemia (CML) in children and adults;

— Use at: Ph + CML in chronic phase at the failure of previous treatment with interferon alpha or in accelerated phase or blast crisis in children and adults;

— When newly diagnosed Philadelphia chromosome positive (Ph +) acute lymphoblastic leukemia (ALL) in adults in combination with chemotherapy;

— If the patient has relapsed or refractory Ph + ALL in adult patients as monotherapy;

— Used for the treatment of myelodysplastic / myeloproliferative diseases associated with gene rearrangement platelet-derived growth factor receptor, in adults;

— Drug affects systemic mastocytosis adult patients with no c-Kit D816V mutation of unknown or c-Kit mutation status;

— Hypereosinophilic syndrome and / or chronic eosinophilic leukemia in adults with a positive or negative abnormal FIP1L1-PDGRF alpha tyrosine kinase;

— Used for unresectable and / or metastatic malignant gastrointestinal stromal tumors positive for c-Kit (CD 117) adult patients;

— Adjuvant treatment of gastrointestinal stromal tumors positive for c-Kit (CD 117) in adult patients;

— Patient has inoperable, recurrent and / or metastatic dermatofibrosarcoma protuberans in adult patients.



— Tell your doctor if you have hypersensitivity to imatinib and other ingredients;

— Pregnancy;

— You should not take the medication during lactation (breastfeeding);

— Children under 2 years of age (efficacy and safety has not yet been established).

With careful preparation can be appointed to persons:
— Patients with severe hepatic impairment, severe renal impairment. The physician should to adjust the dose.
— In patients with cardiovascular disease.
— In the presence of risk factors for heart failure
— During regular hemodialysis.

If you have one of these diseases before taking this medication should always consult with a physician.

Side effects:

Neutropenia, thrombocytopenia, anemia, headache, indigestion, swelling, weight gain, nausea, vomiting, diarrhea, myalgia, muscle cramps, rash, weakness, pain in the abdomen. Most of these adverse events were mild or moderate.

Infectious and parasitic diseases: rarely occurs herpes simplex, herpes zoster, nasopharyngitis, pnevmoniya1, sinusitis, an inflammation of the subcutaneous tissue, upper respiratory tract infection, influenza, urinary tract infection, gastroenteritis, septicemia; rare — the patient gets mycoses.

Sometimes it: benign, malignant and unspecified neoplasms (including cysts and polyps): rarely — tumor lysis syndrome.

The drug causes blood disorders and lymphatic system: very often — neutropenia, thrombocytopenia, and anemia; often — pancytopenia, febrile neutropenia; infrequently — thrombocythemia, lymphopenia, inhibition of bone marrow hematopoiesis, eosinophilia, lymphadenopathy; rarely — hemolytic anemia. Tell your doctor about side effects.

Violations by metabolism and nutrition: often — anorexia; rarely — hypokalemia, increased or decreased appetite, hypophosphataemia, dehydration, hyperuricemia, gout, hypercalcemia, hyperglycemia, hyponatremia; rarely — hyperkalemia, hypomagnesemia. Dosage is adjustment.

The drug can cause mental disorders: often — insomnia; rarely — depression, anxiety, decreased libido; rarely — confusion.

Disorders of the nervous system: very often — headache; often — dizziness, paresthesia, taste disturbance, hypoesthesia. Infrequently, patients talk about migraine, somnolence, syncope, peripheral neuropathy, memory impairment, sciatica, restless leg syndrome, tremor, hemorrhagic stroke; rarely — increased intracranial pressure, convulsions, optic neuritis.

Sometimes the drug causes Violations of the organ of vision: often — swelling of the eyelids, increased lacrimation, conjunctival haemorrhage, conjunctivitis, dry eye syndrome, blurred (blurred vision); infrequently — eye irritation, eye pain, orbital edema, hemorrhage in the sclera of the eye, retinal hemorrhage, blepharitis, macular edema; rarely — cataract, papilledema, glaucoma.

There were cases Violations by the organ of hearing and labyrinth disorders: rarely — vertigo, tinnitus, hearing loss.

Heart problems: Infrequent — palpitations, hronicheskaya3 heart failure, pulmonary edema, tachycardia, prilivy4; rarely — arrhythmias, atrial fibrillation, sudden cardiac arrest; myocardial infarction, angina pectoris, pericardial effusion, increased blood pressure, hematoma.

Irregularities were detected by the vessels: rare — bleeding; rarely — bruising, cold extremities, lower blood pressure, Raynaud’s syndrome.

Irregularities were detected by the respiratory system of the chest, mediastinum: often — nosebleeds, shortness of breath, cough; infrequently — pleural vypot5, pain in the throat or larynx, throat; rarely — pleuritic chest pain, pulmonary fibrosis, pulmonary hypertension, pulmonary hemorrhage.

More often than not there is a violation of the digestive system: very often — nausea, vomiting, diarrhea, indigestion, pain in zhivote6; often — bloating, flatulence, constipation, gastroesophageal reflux disease, xerostomia, gastritis; rarely patients have stomatitis, ulceration of the mucous membranes of the mouth, gastrointestinal bleeding, belching, melena, esophagitis, ascites, gastric ulcer, vomiting blood, cheilitis, dysphagia, pancreatitis; rarely — colitis, paralytic / obstructive ileus, intestinal inflammation.

There are cases of violations of the liver and biliary tract: often elevated liver enzymes, rarely — jaundice, hepatitis, hyperbilirubinemia, rarely — liver failure, necrosis pecheni9.

Patients have Dermatological reactions, such as: — swelling, dermatitis, eczema, skin rash; often — swelling of the face, itching, dry skin, erythema, alopecia, night sweats, photosensitivity reactions; infrequently — pustular rash, petechiae, increased sweating, rash, ecchymosis, increased susceptibility to bruise, hypotrichosis, hyperpigmentation / hypopigmentation of the skin, exfoliative dermatitis, nail damage, folliculitis, petechiae, psoriasis, purpura, bullous eruption; rarely — acute febrile neutrophilic dermatosis (Sweet’s syndrome), discoloration of nails, angioedema, erythema multiforme, leykoplastichesky vasculitis, Stevens-Johnson syndrome, acute generalized pustular rash.

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