Drug Information: Indications, Side Effects, Warnings
Generic Droxia is used for treating skin cancer, cancer of the ovary or chronic myelocytic leukemia that is recurrent, has spread or cannot be helped with surgery. It may also be used with radiation to control skin cancers of the head and neck.
Manufacturer: Baramhaj Chemicals
Generic Droxia is a phase-specific cytotoxic drug (antimetabolite, according to some sources — alkylating action) operating in the S phase of the cell cycle.
Generic Droxia inhibits the growth of cells in interphase G1-S.
After intake, the drug is rapidly absorbed from the gastrointestinal tract. Ingestion not affect the absorbability of the drug.
Indications for use of the drug:
— Chronic myelogenous leukemia;
— Polycythemia vera (erythremia);
— The state of essential thrombocythemia;
— Used in melanoma;
— Malignant tumors of the head and neck, except lip cancer (in combination with radiation therapy);
— Is used for cervical cancer (in combination with radiation therapy).
From the side of hematopoiesis: leukopenia, anemia, thrombocytopenia may occur.
-with Side of the digestive system: stomatitis, bleeding gums, anorexia. Sometimes there are: nausea, vomiting, diarrhea or constipation, ulceration of the gastrointestinal mucosa.
— Increase in liver enzymes.
-with the skin and skin appendages: Common: makulezno-papular rash, erythema of the face and peripheral erythema, dermatitis, myositis skin changes. In some cases, as a result of the daily use of the drug for several years in patients was symptoms such as hyperpigmentation, erythema, atrophy of skin and nails, scaling, violet papules. Rare: alopecia, skin cancer.
From the nervous system: Common: headache, dizziness, fatigue, drowsiness, disorientation; Patients sometimes talked about hallucinations and convulsions.
Urinary: may be an increase of uric acid, blood urea nitrogen and creatinine in blood plasma. Often may be observed urinary retention, interstitial nephritis. In rare cases may be dysuria.
Other side effects include fever, malaise, increased erythrocyte sedimentation rate. Often may be allergic skin reactions, impaired fertility (azoospermia, cessation of menstruation). Sometimes may be pulmonary reactions such as diffuse infiltration of the lungs, fever and dyspnea.
Contraindications of Generic Droxia:
— Leukopenia below 2,500 cells / mm;
— Thrombocytopenia below 100,000 cells / mm;
— Do not take the medication during pregnancy;
— While taking the drug should stop breastfeeding;
— Hypersensitivity to hydroxyurea or any-other auxiliaries, members of the drug.
Can be used with caution in hepatic and / or renal failure, anemia (must be Adjusted pre-treatment).
Treatment should be under medical supervision. Before and periodically during treatment is necessary to check the function of the bone marrow, kidneys and liver. Control the level of hemoglobin, white blood cells and platelets must be carried out at least 1 time per week throughout the treatment period.
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