Imuran (Azathioprine)

Drug Information: Indications, Side Effects, Warnings

Category:  Arthritis, Surgery

Generic Imuran may also be used to treat signs and symptoms of active rheumatoid arthritis, and it is used for preventing kidney transplant rejection along with other medicine.Imuran 100 TABLETS

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Nosological classification (ICD-10):

D55-D59 Hemolytic anemia
D69.3 Idiopathic thrombocytopenic purpura
K73 Chronic hepatitis, not elsewhere classified
L10 Pemphigus [pemphigus]
M05 seropositive rheumatoid arthritis
M30 polyarteritis nodosa and related conditions
M32 Systemic lupus erythematosus
M33 dermatopolymyositis
T86 dieback and rejection of transplanted organs and tissues

Coated tablets.

 

Each tablet contains:
azathioprine (basic substance) — 50 mg
Other ingredients: lactose monohydrate; corn starch; pregelatinized starch; magnesium stearate; stearic acid. Coated tablet: gipermelloza; macrogol 400 (granulation shell and applying the solvent is purified water, which is removed in the manufacturing process and the finished product is not present)

 

Pharmacological action:

Pharmacological action — immunosuppressive, cytotoxic, antitumor.

The drug blocks cell division as a result of competition with the natural purine bases of DNA and RNA.

 

Pharmacodynamics:

— Drug inhibits the growth and development of immune cells (lymphocytes, plasma cells)
— A cooperative effect on the immune response (T-lymphocytes, macrophage-B-lymphocytes)
— Inhibits the migration of stem cells.

At high doses (10 mg / kg) inhibits the function of bone marrow
— Inhibits the proliferation of granulocytes
— Cause leukopenia.

 

Indications for use:

Organ transplantation, severe rheumatoid arthritis, systemic lupus erythematosus. Also, the drug used in the treatment of: dermatomyositis, chronic active hepatitis, pemphigus vulgaris, polyarteritis nodosa. There is a good result in the treatment of haemolytic anemia, chronic idiopathic thrombocytopenic purpura.

 

Imuran is also used in the following conditions:
1) In diseases that are not treated with corticosteroids alone; 2) When diseases which can be treated with corticosteroids at doses causing severe adverse reactions. 3. The drug is used to reduce the need for steroids; 3) In cases where the use of corticosteroids is contraindicated. 4. The product exhibits a significant therapeutic activity without corticosteroids in the treatment of pemphigus vulgaris and rheumatoid arthritis.

Contraindications:

Hypersensitivity (including a 6-mercaptopurine).

Pregnancy and breast-feeding:

Contraindicated.

Side effects:

Mielodeprescia (leukopenia, thrombocytopenia, anemia), megaloblastic erythropoiesis and macrocytosis. There may also be nausea, vomiting, anorexia, rash, arthralgia, myalgia, drug fever. Sometimes: cholestatic hepatitis, development of secondary infections;
The drug can cause transplant recipients:
— Erosive and ulcerative lesions and bleeding from the gastrointestinal tract
— Pancreatitis
— Necrosis and perforation of the bowel.
Rarely — acute renal failure, hemolytic anemia, acute lung disease, meningeal reaction.

Mutagenicity. The drug is potentially mutagenic and causes chromosomal abnormalities in humans. Damage may be reversible after discontinuation of the drug.

Impact on fertility: The drug has no inhibitory effect on fertility in women or men.

Carcinogenicity: In transplant recipients:
— An increase in the incidence of malignant tumors (especially epithelial and lymphoreticular).
— Skin tumors develop on areas of skin exposed to sunlight.
— Patients should be warned about the inadmissibility of prolonged exposure to the sun. Need for regular inspection of the skin.

 

Overdose. It should be symptomatic treatment. Azathioprine is removed by dialysis, however, in severe cases can be applied dialysis.

Storage conditions. The tablets were stored at temperatures below 35 ° C and in a dry, dark place

 

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