Atripla (Efavirenz+emtricitabine+tenofovir)

Drug Information: Indications, Side Effects, Warnings

Category: antivirals, hiv

Generic Atripla is an antiviral medication that prevents human immunodeficiency virus (HIV) from reproducing in your body.

Brand(s): ViradayAtripla online

Manufacturer: Cipla

Dosage form:

Coated tablets.

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Pharmacy therapeutic group:

Antiviral agents for the treatment of HIV infection, the combination.

Indications for use:

As monotherapy or in combination with other antiretroviral agents for the treatment of infection by human immunodeficiency virus 1 (HIV-1).

 

Contraindications:

-Hypersensitivity to thedrug.

-Hepatic failure, severe (grade C on the scale of Child — Pugh).

The recommended dose of Atripla for adults is 1 tablet into 1 time per day. Swallow the tablet whole with its water. Take on an empty stomach.

Side effects:

 

The most common side effects (with a frequency ≥ 10%, any severity) were diarrhea, nausea, headache, dizziness, depression, insomnia, sleep disorders and rashes.

Frequency: very common (≥ 1/10), often (≥ 1/100, <1/10), sometimes (≥ 1/1000, <1/100) and rare (≥ 1/10 000 <1/1000) .

Blood and lymphatic system, circulatory disorders

Common: flushing. Rare: neutropenia, anemia.

From the heart: increased heart rate.

On the part of the respiratory, thoracic and mediastinal disorders. Rare: shortness of breath, cough increased, pneumonia, rhinitis.

Gastro — intestinal tract. Very common: nausea, diarrhea, vomiting. Common: abdominal pain, nausea, dyspepsia, flatulence and bloating, dry mouth. Rare: anorexia, acute pancreatitis, constipation *, * malabsorption.

Kidney and urinary tract: renal failure (acute and chronic forms), acute tubular necrosis, proximal tubulopathy including Fanconi syndrome, nephritis, acute nephritis, nephrogenic diabetes, elevated levels of creatinine, proteinuria, proximal tubulopathy, polyuria.

Allergies: For the skin and subcutaneous — adipose tissue. Very common: rash (all forms). Common: redness, hyperpigmentation of the skin, dermatitis, edema. Uncommon: rash, dry skin, eczema, Stevens — Johnson syndrome, severe rash, flushing *, erythema multiforme, disorders of the nails, fotoalergiyny dermatitis.

Musculoskeletal dvigatelnoy apparatus: myopathy, osteomalacia (both disorders are associated with proximal renal tubulopathy), arthralgia, myalgia, back pain *.

General disorders and local disorders at the site of injection. Common: fatigue, fever, pain, asthenia. Rare: feeling of intoxication.

By the immune system. Rare: hypersensitivity, allergic reactions *.

On the part of the liver. Uncommon: acute hepatitis, liver failure *.

Reproductive system, mammary glands. Uncommon: gynecomastia.

Metabolism: Redistribution / accumulation of body fat (see. «Features of the application»). Hypercholesterolemia, hypertriglyceridemia.

Infection. Common: sinusitis, infections of the upper gastro — intestinal tract, nasopharyngitis.

Nervous system, the body of the organ of hearing and balance. Very common: dizziness, headache. : Sleep disturbance, drowsiness, insomnia, stupor, attention disorders, lethargy, impaired attention. Rare: seizures, visual disturbances, amnesia, ataxia, impaired balance, taste disturbance, agitation; ringing in the ears * violations cerebellar coordination and balance * * hypoesthesia, paresthesia * * neuropathy, tremor *.

Psychoneurotic disorders. Very common: obsessive dreams. Common: nightmares, depression, insomnia, anxiety, sleep disturbance, a state of euphoria. Uncommon: paranoid state, agitation, delirium, depression state, disorientation, anxiety, aggression, neurosis, suicide attempt, suicidal ideation, delusions, paranoid state, hallucination, euphoric state, a state of passion, depression. Laboratory abnormalities. Very: increased CPK, hypophosphatemia. : Increased amylase, including pancreatic amylase, serum lipase increase, hyperglycemia, hypertriglyceridemia, hyperbilirubinemia, elevated liver enzymes *.

Overdose:

Exacerbation of symptoms observed in the nervous system, involuntary muscle contractions.

Use during pregnancy and lactation:

The drug Atripla should not be used during pregnancy

Children:

Atripla is not recommended for use in children

Date of Expiry:

 

3 years. Do not use after the expiry date printed on the package.

Storage conditions. Store at temperatures above 30 ° C.

 

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