Lotrisone: anti-fungal cream and lotion

Lotrisone is an anti-fungal cream and lotion. It comprises of two medicine: betamethasone dipropionate and clotrimazol.

Lotrisone Uses

Betamethasone dipropionate (hereinafter refer to as B.D.) is a strong steroid which can releave itchiness, redness of skin and reduce a tumor. Clotrimazole is an anti-fungal.

Brand(s): Lotrisone

Manufacturer: Merck Sharp and Dohme Corporation

Clinico-pharmacological group:

Lotrisone cream is equivalent of a clotrimazole. But it wasn’t conducted any researches on studying of the main properties of Lotrisone lotion and a clotrimazole yet. The long use of conticosteroids can bring to deterioration or decrease of efficiency of treating at treating infections caused by fungi.


Clotrimazole is the antimicotic medicinal substance. The mechanism of action of Clotrimazole is based on its ability to break synthesis of substances of a cellular membrane of fungi that leads to its perforation, disturbance of body height and development of fungi and their death. Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, Epidermophyton floccosum, Candida albicans and Malassezia furfur are sensitive to action of Clotrimazole.

Types of the fungi which have stable to a clotrimazol meet seldom.

It is badly soaked up through skin and mucous membranes.

B. D.

B. D. is the synthetic strong steroid possessing the expressed antiinflammatory, anti-exudative, antipruritic and antiallergic action. B. D. oppresses release the lysosomal enzymes and pro-inflammatory cytokines in the inflammation center, slows down accumulation of leucocytes, reduces a phagocytosis and reduces vascular and fabric permeability.


Linkng with proteins of plasma makes about 64%, Vd — 84 l. It’s metabolized in a liver. Metabolites are removed mainly by kidneys, insignificant part — with bile.

At absorption through skin of beta metazones it is characterized by similar pharmacokinetic properties, both at external, and at system application. System absorption after external application makes 12-14%.

At local and external application at intact skin absorption can be insignificant. Existence of inflammatory process, and also application of an occlusive bandage, can increase absorption volume.

Composition, structure and packing

If to look at a chemical composition of a Clotrimazole: It has formula C22H17ClN2, and the structure:

Clotrimazole is a white transparent powder without smell. It isn’t soluble in water, but well soluble in ethanol.

B. D. the chemical formula C28H37FO7 and the structure:

B. D. is a white or creamy-white powder without smell. It’s insoluble in water.

Preparation for external using of Lotrisone on 15 or 45 g in tubas from aluminum, in a cardboard pack 1 tuba. It’s white or off-white color. Irrespective of a release form it’s necessary to store a preparation max 2 years at the room temperature.

Basic ingredient: clotrimazole and B.D.

Other ingredients:

The medicine consist of such elements as benzyl alcohol, cetyl alcohol and stearyl alcohol, mineral oil, phosphoric acid, propylene glycol, purified water and others

The composition of the coating film:

The structure of Lotrisone may consist of sodium hydroxide. The medicine is an uniform, white or dirty white.


Lotrisone cream and lotion are intended for external application. It’s necessary to escape hit of medicine in eyes and on a skin round eyes. Use of occlusive bandages over the preparation isn’t recommended.It isn’t for using by children. The medicine should be applied with a thin layer, avoiding active rubbing in of a preparation. Duration of treatment and a dose of a preparation is prescribed by the doctor.

It’s need to use this medicine twice per day on affected areas. Depending on gravity and a form of a disease the doctor can change frequency rate of application.

Duration of treating by a preparation makes from 2 to 4 weeks.

It isn’t necessary to use a preparation on face skin max 5 days in a row as this site of an integument is more subject to atrophic changes when using betamethasone.

In case if from 3 to 7 days it doesn’t become perceptible positive dynamics, it’s necessary to cancel a preparation and to specify the diagnosis.

After long use the preparation should be cancelled gradually.


About development of an acute overdosage at external application of this preparation it wasn’t reported. At long application of high doses (max 45 g) of a preparation for patients possibly development of a chronic overdosage of betamethasone. At a chronic overdosage of betamethasone at patients possibly development of signs of a hypercorticoidism.

Side effects

At superficial application of the preparation lotrisone possibly development of such undesirable effects as itch, burning sensation, dryness and boring of integuments, hypertrichosis, folliculitis, pigmentation disturbances, allergic contact dermatitis and perioral dermatitis. When drawing a preparation under an occlusive bandage possibly development of an atrophy and maceration of a skin, heat rash and a secondary infection. At long application of high doses of a preparation possibly development of the systemic undesirable effects caused by active components. In particular the hyperglycemia, oppression of a cortex of adrenals, a glucosuria, disturbances of a menstrual cycle, an osteoporosis, arterial hypertension belong to systemic undesirable effects. Besides, development of ulcerations of a mucosa of a digestive tube, sleeplessness and an exacerbation of the hidden centers of an infection is possible. At development of reactions of a hypersensitivity a preparation it is necessary to cancel and pick up alternative therapy.

Indications for use

Lotrisone cream is a mixture of an anti-fungal and corticosteroid. It’s appointed for the topical treating of infections caused by fungi at patients older than 17 years.



Where to buy?

You can get it in pharmacy.