Wellbutrin: Treating of a depression

Wellbutrin group

Wellbutrin is intended for treating of a depression.

Brand(s): Wellbutrin, Wellbutrin SR, Wellbutrin XL

Manufacturer: GLAXOSMITHKLINE

If you take Wellbutrin for depression, do not also take Zyban to quit smoking.

If you take Wellbutrin for depression, do not also take Zyban to quit smoking.

Clinico-pharmacological group:

Efficiency and shipping of the preparation was investigated in 7 double blind researches; from these 7 researches, 3 were carried out in Europe in the interesting dose range (up to 300 mg/days). The following 4th researches were conducted in the USA with a flexible range of doses up to 450 mg/days.

The proof of long- term support of effect is provided with 1 years’ research of prophylaxis of exacerbations with the bupropion; 816 patients received bupropion in a phase of unilateral blind reception of this research from which 423 were randomized in the subsequent double blind phase (bupropion — 210, placebo — 213).

Bupropion was effective at patients with gravity of a depression from mild to moderate, as well as for patients with a serious depression. In the joint comparative European researches similar degrees of superiority of a preparation over placebo were noted as at patients with a depression mild and moderately severe (-1.8, —Ä = 0,032), and at patients with a serious depression (-2.3, r=0,041).

Composition, structure and packing

The tablets covered with a cover from creamy white till pale yellow color, round, with marking of «GS5FV» of black color on one part. It contains 150 mg of a bupropion.

7 pieces — the bottle from high density polyethylene containing the container with a desiccant. The pack is cardboard.

30 pieces — the bottle from high density polyethylene containing the container with a desiccant. The pack is cardboard.

90 pieces — the bottle from high density polyethylene containing the container with a desiccant. The pack is cardboard.

The tablets covered with a cover from creamy white till pale yellow color, round, with marking of » GS5YZ» of black color on one part. It contains 300 mg of a bupropion.

7 pieces — the bottle from high density polyethylene containing the container with a desiccant. The pack is cardboard.

30 pieces — the bottle from high density polyethylene containing the container with a desiccant. The pack is cardboard.

Basic ingredient: bupropion hydrochloride

Other ingredients: hydroxypropyl cellulose, hypromellose, microcrystalline cellulose, talc, and titanium dioxide.

The composition of the coating film: ethyl-cellulose-100, povidone, macrogol-1450, methacrylic acid and ethyl acrylate copolymer [1:1] (contains 0.7% of SDS, 2.3% of polysorbat -80), silicon dioxide, triethyl citrate, the black ink.

Dosage: the preparation needs to be swallowed entirely, without chewing as it can bring to augmentation of risk of emergence side effects, including convulsive disorders.

Treating of a depression

The clinical effect appears in 2 weeks after the beginning of the treating.

The limit dose of the preparation has to be max 450 mg. Interval between acceptance of the medicine there have to be 24 hours. It’s necessary to raise a dose max on 100 mg a day within three days.

Adults

The initial dose of the preparation makes 150 mg once a day, in the morning.

If it isn’t observed a positive effect then recommended to enlarge a dose to 300 mg/days of 1 times per day.

If it isn’t observed a positive effect after treatment of several weeks of therapy in a dose of 300 mg/days then recommended to enlarge a dose to 450 mg of 1 times/days.

Maintenance therapy

–źt a cafard demand continuous treating lasting from 6 months after achievement of the initial therapeutic answer. Efficiency of the preparation (300 mg/days) is proved at long therapy (till 1 year).

Children and teenagers

Safety and efficiency of the preparation at patients aged till 18 years isn’t established.

Treating of a depression at special groups of patients

At elderly patients probably hypersensitivity reaction development therefore it’s necessary to lower a dose of reception of a preparation.

Patients with dysfunction of kidneys

Treating of such patients has to be begun with a smaller dose of the medicine. It’s metabolites can collect at such patients more than usually. The preparation shouldn’t overdraw 150 mg once a day.

Patients with dysfunction of a liver

For such people the augmentation of an interval between receptions of a preparation can be demanded.

The dose of the medicine shouldn’t overdraw 150 mg of 1 times in 2 days.

Overdose: A sleepiness, a loss of consciousness and changes on an ECG, such as conduction disturbances (including elongation of the QRS complex), arrhythmias. It was reported about a case of single-step intake of the preparation in the doses, by 10 times exceeding the limit therapeutic dose.

Side effects: anorexia, headache, hyperventilation, irregular heartbeats, irritability, dizziness, visual disturbances, shortness of breath, sleeplessness, ring in ears, rising of arterial pressure and the others

Indications for use: This preparation is indicated for the treating of major depressive disorder.

Contraindications

  • hypersensitivity to a Wellbutrin or any other component of a preparation;
  • convulsive disorders;
  • sharp cancellation of alcohol intake or sedatives (including benzodiazepines);
  • the accompanying application of others preparations which consist of a bupropion (emergence of cramps is dose-dependent effect);
  • a bulimia or a nervous anorexia in the anamnesis (emergence of cramps is possible);
  • the accompanying application with MAO inhibitors. It isn’t necessary to begin therapy with bupropion at least after 2 weeks after cancellation of irreversible inhibitors of MAO;
  • age till 18 years.

it’s necessary with care to apply at patients with dysfunction of a liver, dysfunction of kidneys, cardiovascular diseases and the lowered threshold of convulsive readiness.

Where to buy?

You can get the preparation in pharmacy.