Endep Tablets (Amitriptyline hydrochloride): Consumer Medicines Information

Endep Tablets

Endep is a medication against symptoms of major depression and for some central nervous system disorders. It also can be taken in cases of bed-wetting caused by non-physical reasons.

Endep Tablets

Endep Tablets

Brand(s): Endep.

Manufacturer: Roche Laboratories.

Clinico-pharmacological group: Tricyclic antidepressants (TCA).

Composition, structure and packing: 10mg, 25mg, 50mg and 75mg tablets.

  1. 10mg – orange, round, film-coated, with «ENDEP 10 ROCHE» imprint.
  2. 25mg – orange, round, film coated, with «ENDEP 25 ROCHE» imprint.
  3. 50mg – orange, round, film coated, with «ENDEP 50 ROCHE» imprint.
  4. 75mg – yellow, round, film coated, with «ENDEP 75 ROCHE» imprint.

Basic ingredient: Amitriptyline hydrochloride – 10mg, 25mg, 50mg or 75mg.

Other ingredients: lactose (milk sugar), colloidal silicon dioxide, magnesium stearate, pre-gelatinized corn farina, di-sodium edetate, sodium farina glycolate.

The composition of the coating film: microcrystalline cellulose, refined talcum, opadry (with colorants).

Dosage: Depends on the patient’s condition and should be determined by a specialist. Dosage must be started at low levels and could be raised gradually as a result of positive response and tolerance. Increases are preferably closer to the end of a day or before the bedtime.

Depression

Initial dose is varied, as a rule, from 75mg/day to 150mg/day in divided doses for outdoor patients.

For patients in hospitals starting dose may be 100mg/day with the following increase up to 200mg/day. In some exceptional cases daily dose may reach 300 mg/day.

Generally, lower doses are recommended for older persons to reduce the risk of an intolerance.

Maintenance doses usually reduced to 50-100 mg/day on symptoms improvement and satisfied response.

Bed-wetting (enuresis)

For kids under 6 years the recommended dosage is 10mg daily before the bedtime. For older patients’ daily dose might be increased, if necessary, depending to their age, weight and condition. For 6-10 years’ group it can reach 20mg/day. Children starting from 11 to 16 years may receive from 25 to 50mg/day.

The response of patients mostly must be clearly appeared in a few days after taking. If response is detected, the period of therapy could be extended.

For enuresis cases recommended doses are lower than with those for depression treatment and should not be exceeded.

Missed doses

If dose is missed, it is advised to take it as soon as possible. Before the times of next doses, it is strongly recommended to skip the missed dose in favor of the planned schedule.

Overdose

Temporary confusion, concentration disturbances, visual hallucinations. Possible effects: sleepiness, hypothermia, arrhythmic disorders such as increased heart ratio, bundle branch stoppage, congestive, conduction failures, dilated pupils, spasms, serious blood pressure lowering, torpor, coma and polyradiculoneuropathia.

ECG deviations, especially in QRS axis or breadth is one of factors of clinical evidence of TCA overdosage.

Other symptoms: anxiety, hyperactivity, muscle hardness, vomiting.

Mortal issues also have been registered with that medicine category.

Side effects

Cardiovascular – low blood pressure, high blood pressure, faint, palpitation, heart attack, heart beating abnormal rhytmes, heart stoppage, paralysis, ECG and AV conduction results changes.

CNS and neuromuscular – confusion, concertation disturbances, poor orientation, illusions, hallucinations, agitation, worry, unrest, sleeplessness, drowsiness, scares, insensitivity, tingling, extremities sense disorder, peripherial neuropathy, bad coordination, ataxy, shiver, strokes, coma, deviations in EEG, involuntary movements, difficult articulation, buzzing in the ears.

Anticholinergic – dryness in the mouth, unclear vision, hard defecation, iliac passion, delayed urination, high intraocular tension, hypothermia.

Allergic reactions – eruption, hives, itch, skin photosensitization, facial and tongue edemas.

Hematological – bone marrow disorders (deficiency of white blood cells, leukopenia, eosinophilia, deficiency of platelets), small blood vessels bleeding.

Gastrointestinal – sickness, gastric ailment, anorexy, stomatitis, strange tinge, diarrhea, parotid lumps, liver diseases (jaundice, hepatite etc.).

Endocrine system – testis swelling and gynecomastia (men), breast enlargement and spontaneous lactation (women), low or high libido levels, impotency, bloog sugar deviations, inadequate ADH secretion.

Other – vertigo, weakness, tiredness, migraine, weight hesitations, edema, increased sweating, frequent urination, baldness.

Indications for use

Major depression;

  1. Bed-wetting (nocturnal enuresis).
  2. Contraindications:
  3. Hypersensitivity to amitriptyline or other trucyclic compounds;
  4. Epileptic seizure;
  5. Glaucoma;
  6. Chronic bowel obstruction;
  7. Bad metabolizing;
  8. Heart attack aftermath;
  9. Heart beating disorders;
  10. Increased Q-T interval in ECG results;
  11. Low blood pressure;
  12. Bowel paralysis;
  13. Liver diseases;
  14. Enlarged prostate;
  15. Problems with empting an urinary bladder;
  16. Hyperactive thyroid gland;
  17. Dangerous mental problems (manias, suicidal moods);
  18. Large alcohol consumption.

Where to buy?

Endep is available in pharmacies and can be ordered with discount online at Super Online Pharmacy (without prescription).