Drug Information: Indications, Side Effects, Warnings
Category: Â Antidepressants
Generic Effexor affects chemicals in the brain that may become unbalanced and cause depression, is used to treat major depressive disorder, anxiety, and panic disorder.
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Brand(s): Ventab / Venpad
Manufacturer: Intas / Tripada
The main substance: venlafaxine
Therapeutic agents venlafaxine:
Nosological classification (ICD-10):
F32 depressive episode
F33 Recurrent depressive disorder
Indications for use include the treatment of depression and the prevention of its recurrence.
After intake of venlafaxine is well absorbed and extensively metabolized in the liver.
Dependence on the pharmacokinetic parameters of certain factors:
Age and sex:
Population pharmacokinetics analysis in 404 patients treated with venlafaxine during the 2 studies (including taking the drug twice and three times a day), suggests that age and gender did not affect the pharmacokinetic parameters of venlafaxine.
Abnormal liver function:
In 9 patients with cirrhosis pharmacokinetic parameters were significantly changed after taking the drug:
Impaired renal function:
in patients with impaired renal function (glomerular filtration rate of 10-70 ml / min) was noted:
— Increase in T1 / 2 of venlafaxine approximately 50%
— Decrease in clearance by about 24%.
Carcinogenicity, mutagenicity, effects on fertility:
Studies in rats have shown that when administered to animals venlafaxine (120 mg / kg / day for 18 months (mice) and 24 months (rat)) the incidence of tumors did not increase.
In studies in rats revealed no effects on fertility in male and female rats when administered to animals large doses.
The drug is indicated for the treatment of depression, generalized anxiety disorder, social phobia, panic disorder.
-Hypersensitivity, simultaneous reception of MAO inhibitors.
Restrictions apply to:
— Recent myocardial infarction and unstable angina
— Changes in blood pressure, increased intraocular pressure and angle-closure glaucoma. Consult a physician.
— Mania in history
— Initially underweight. Need a set of body weight dose adjustment.
— Renal / hepatic failure
-Age to 18 years (safety and efficacy have not been established).
Pregnancy and breast-feeding:
Use during pregnancy is possible only in case of emergency. There had been no adequate and well-controlled studies safety of pregnant women).
In clinical practice, was marked by a number of adverse effects in newborns if their mothers took venlafaxine and other serotonin reuptake inhibitors just before birth. Among these effects: respiratory distress, cyanosis, apnea, seizures, temperature instability of the body, vomiting, hypoglycemia, hyperreflexia, tremor, irritability, continuous crying.
No known effect on venlafaxine hydrochloride on generic activities for women.
Side effects associated with the abolition of the drug:
— drowsiness 3% (1%), insomnia 3% (1%), dizziness 3% (<1%) Headache 3% (1%), anxiety 2% (1%), nervousness 2% (<1%) , asthenia 2% (<1%); dry mouth 2% (<1%), nausea 6% (1%), abnormal ejaculation 3% (<1%), sweating 2% (<1%).
Side effects, drug-induced:
— Asthenia, sweating, nausea, constipation, anorexia, and vomiting. It may also be: drowsiness, dry mouth, dizziness, nervousness. Sometimes: anxiety, tremors, blurred vision, abnormal ejaculation / orgasm and impotence in men.
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