Аapplication of Mirtazapine

Mirtazapine is a tetracyclic antidepressant used to heal depression and posttraumatic stress disorder.

Therapeutic agents Mirtazapine

Antidepressants

The nosological classification (ICD-10)

F32 Depressive episode

F33 Recurrent depressive disorder

Contraindications of Mirtazapine

Hypersensitivity, simultaneous reception of MAO inhibitors.

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Restrictions apply of Mirtazapine

Epilepsy and organic brain damage (may develop convulsions); heart disease (conduction disturbances, angina or recent myocardial infarction); cerebrovascular disease (including ischemic attack history); hypotension, and conditions that predispose to hypotension (including dehydration and hypovolemia); drug dependence and the propensity to abuse drugs (in history); mania, hypomania; impaired urination, including prostatic hyperplasia; Acute angle-closure glaucoma, increased intraocular pressure; diabetes; liver and / or kidney failure; age 18 years (safety and efficacy not established).

Side effect of Mirtazapine

From the nervous system and sensory organs: drowsiness, 54% (18%), asthenia 8% (5%), dizziness 7% (3%), abnormal dreams 4% (1%), abnormal thinking processes 3% (1%) tremor 2% (1%), confusion, 2% (0%).

From the digestive tract: dry mouth 25% (15%), increased appetite 17% (2%), constipation 13% (7%).

Other: weight gain of 12% (2%), a flu-like syndrome, 5% (3%), back pain 2% (1%), myalgias 2% (1%), increased 2% urination (1%), peripheral edema 2% (1%), dyspnea 1% (0%).

Overdose of Mirtazapine

Symptoms: lethargy, drowsiness, disorientation, tachycardia, hallucinations, increased or decreased blood pressure.

Treatment: gastric lavage, activated charcoal, symptomatic and supportive therapy.

Dosing and Administration

Inside, the bed, the initial dose — 15 mg / day, the effective dose is usually 15-45 mg / day. In renal and hepatic insufficiency daily dose should be reduced by about 1/3. The course of treatment — 4-6 months.