Drug Information: Indications, Side Effects, Warnings
Generic NeggramÂ (Nalidixic Acid)
Urinary Tract,Â Antibiotics
The antimicrobial agent, a quinolone
Description of the active substance :
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Antibacterial substance . Inhibits DNA synthesis by inhibiting its polymerization. Effective against gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Friedlander’s bacillus. Bacteriostatic or bactericidal effect (depending on the sensitivity of the microorganism and concentration). Susceptible strains of microorganisms that are resistant to antibiotics and sulfonamides. Inactive against Gram-positive organisms and anaerobes. In the course of treatment may develop resistance of microorganisms.
Pyelonephritis, cystitis, urethritis, prostatitis; gastrointestinal infection, cholecystitis, etc., caused by susceptible microorganisms. Infection prevention during operations on the kidneys, ureters, urinary bladder.
Hypersensitivity, liver and / or kidney failure, epilepsy, cerebral atherosclerosis (severe), pregnancy, children’s age (up to 2 years), lack of glucose-6-phosphate dehydrogenase.
Nausea, vomiting, diarrhea, gastralgia, bleeding from the gastrointestinal tract, cholestasis; drowsiness, headache, blurred vision and color vision, diplopia, intracranial hypertension, dysphoria, myalgia; allergic reactions (skin rash, itching, angioedema). With prolonged use possible thrombocytopenia, leukopenia, hemolytic anemia, photosensitivity, convulsions.
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Dosage and administration:
Inside, 1 g 4 times a day for 7 days. In carrying out a continuous treatment, the dose may be reduced to 0.5 g 4 times a day. Babies — initial dose of 60 mg / kg, 3-4 hours, maintenance — 30 mg / kg / day in 3-4 divided doses.
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The therapy can be false-positive reaction of urine for sugar.
Should not be administered simultaneously with indirect anticoagulants. May have a depressing effect on the central nervous system, especially in the case of simultaneous application of ethanol or other. Drugs depressing the central nervous system. Incompatible with nitrofurans.
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