Drug Information: Indications, Side Effects, Warnings
Generic LevaquinÂ (Levofloxacin)
The antimicrobial agent — fluoroquinolone
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Fluoroquinolone antimicrobial is a broad spectrum bactericidal action. Blocks of DNA gyrase (topoisomerase II) and topoisomerase IV, and crosslinking gives supercoiling of DNA breaks, inhibits DNA synthesis, causes profound morphological change in the cytoplasm, membrane and cell wall of bacteria. Activity in vitro: Sensitive organisms (minimum inhibitory concentration of less than 2 mg / l). Aerobic gram-positive microorganisms: Corynebacterium diphtheriae, Enterococcus spp. (Including Enterococcus faecalis), Listeria monocytogenes, Staphylococcus spp. (Coagulase metitsillinchuvstvitelnye / moderately susceptible strains), including Staphylococcus aureus (metitsillinchuvstvitelnye strains), Staphylococcus epidermidis (metitsillinchuvstvitelnye strains), Staphylococcus spp. (Leykotoksinsoderzhaschie); Streptococcus spp. Groups C and G, Streptococcus agalactiae, Streptococcus pneumoniae (penitsillinchuvstvitelnye / moderately sensitive / resistant strains), Streptococcus pyogenes, Streptococcus group viridans (penitsillinchuvstvitelnye / resistant strains). Aerobic gram-negative microorganisms: Acinetobacter spp. (Including Acinetobacter baumannii), Actinobacillus actinomycetemcomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter spp. (Including Enterobacter cloacae), Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae (ampitsillinchuvstvitelnye / resistant strains), Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp. (Including Klebsiella oxytoca, Klebsiella pneumoniae), Moraxella catarrhalis (and producing no-producing beta-lactamase strains), Morganella morganii, Neisseria gonorrhoeae (and producing no penicillinase-producing strains), Neisseria meningitidis, Pasteurella spp. (Including Pasteurella canis, Pasteurella dagmatis, Pasteurella multocida), Proteus mirabilis, Proteus vulgaris, Providencia spp. (Including Providencia rettgeri, Providencia stuartii), Pseudomonas spp. (Including Pseudomonas aeruginosa), Serratia spp. (Including Serratia marcescens), Salmonella spp. Anaerobic bacteria: Bacteroides fragilis, Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp., Propionibacterium spp., Veilonella spp. Al. microorganisms: Bartonella spp., Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella spp. (Including Legionella pneumophila), Mycobacterium spp. (Including Mycobacterium leprae, Mycobacterium tuberculosis, Mycoplasma hominis), Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum. Moderately sensitive micro-organisms (minimum inhibitory concentration more than 4-8 mg / l): Aerobic gram-positive microorganisms: Corynebacterium urealyticum, Corynebacterium xerosis, Enterococcus faecium, Staphylococcus epidermidis (methicillin-resistant strains), Staphylococcus haemolyticus (methicillin-resistant strains). Aerobic gram-negative microorganisms: Burkholderia cepacia, Campylobacter jejuni, Campylobacter coli. Anaerobic organisms: Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides ovatus, Prevotella spp., Porphyromonas spp. Resistant bacteria (the minimum inhibitory concentration of more than 8 mg / l): Aerobic Gram-positive microorganisms: Corynebacterium jeikeium, Staphylococcus aureus (methicillin-resistant strains), other Staphylococcus spp. (Coagulase methicillin-resistant strains). Aerobic gram-negative microorganisms: Alcaligenes xylosoxidans. Al. microorganisms: Mycobacterium avium. You can order Generic LevaquinÂ (Levofloxacin) online or buy prescription at the pharmacy. You can buy cheap Generic Levaquin using coupons. Discount can reach up to 80%.
Infections caused by susceptible to levofloxacin pathogens: lower respiratory tract infections (acute exacerbations of chronic bronchitis, community-acquired pneumonia), acute sinusitis, urinary tract and kidney (including pyelonephritis), skin and soft tissues, chronic bacterial prostatitis, septicemia / bacteremia (related with the previous readings), intra-abdominal infections, tuberculosis (complex therapy of drug-resistant forms).
Hypersensitivity, epilepsy, damage to the tendons at the previously held the treatment of quinolones, pregnancy, lactation, childhood and adolescence (18).
From the digestive system: nausea, vomiting, diarrhea (including blood), indigestion, loss of appetite, abdominal pain, pseudomembranous colitis; increased activity of «liver» transaminases, hyperbilirubinemia, hepatitis, goiter. From the CCC: lowering blood pressure, circulatory collapse, tachycardia, prolongation of the interval QT. Metabolism: Hypoglycemia (increased appetite, increased sweating, tremors). From the nervous system: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesia, anxiety, hallucinations, confusion, depression, movement disorders, convulsions. From the senses: visual impairment, hearing, smell, taste and tactile sensitivity. On the part of the musculoskeletal system: arthralgia, muscle weakness, myalgia, tendon rupture, tendonitis. From the urinary system: hypercreatininemia, interstitial nephritis, acute renal failure. From the side of hematopoiesis: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhage. Allergic reactions: photosensitivity, itching, and redness of the skin, swelling of the skin and mucous membranes, urticaria, malignant exudative erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), bronchospasm, asthma, anaphylactic shock, hypersensitivity pneumonitis, vasculitis. Other: asthenia, exacerbation of porphyria, rhabdomyolysis, persistent fever, the development of superinfection.
Dosage and administration:
Inside, before a meal or in between meals, without chewing, drinking plenty of fluids. B / in slowly. In acute sinusitis — 500 mg 1 time per day for 10-14 days. During exacerbation of chronic bronchitis — 250-500 mg 1 time a day for 7-10 days. When CAP — 500 mg 1-2 times a day for 7-14 days. Uncomplicated urinary tract infections — 250 mg 1 time per day for 3 days. In complicated urinary tract infections — 250 mg 1 time per day for 7-10 days. With infections of skin and soft tissue — the inside of 250-500 mg 1-2 times a day; in / in 500 mg 2 times a day for 7-14 days. Septicemia / bacteremia — 500 mg 1-2 times a day for 10-14 days. When intra-abdominal infections — 500 mg 1 time per day for 7-14 days (in combination with antibacterial drugs acting on the anaerobic microflora). In chronic bacterial prostatitis — 500 mg 1 time per day for 28 days. In tuberculosis (in the complex therapy) — 500 mg 1-2 times a day, course of treatment — up to 3 months. After the on / in a few days can pass on the intake at the same dose. When kidney disease dose reduced according to the degree of violation of their functions: with CC 20-50 ml / min — by 125-250 mg 1-2 times a day, 10-19 ml / min — 125 mg 1 time in 12-48 hours less than 10 ml / min (including hemodialysis) — 125 mg every 24 hours or 48 hours. You can LevaquinÂ buy through the Internet, it will cost you cheap.
After normalization of body temperature is recommended to continue treatment for at least 48-78 hours. Duration in / infusion of 500 mg (100 ml infusion solution) must be at least 60 minutes. During treatment should avoid sunlight and artificial UV radiation to prevent damage to the skin (photosensitivity). If signs of tendinitis, pseudomembranous colitis levofloxacin immediately overturned. It should be borne in mind that in patients with brain damage in history (stroke, severe trauma) may develop seizures, with insufficient glucose-6-phosphate dehydrogenase — the risk of hemolysis. In severe community-acquired pneumonia caused by Streptococcus pneumoniae, levofloxacin may not give optimal therapeutic effect. During the period of treatment must be careful when driving and other lesson. Potentially hazardous activities that require high concentration and speed of psychomotor reactions.
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