Dexone (Dexamethasone)

Drug Information: Indications, Side Effects, Warnings

Category: Antibiotics, Antiallergic, Anti-inflammatories

Generic Dexone depresses formation, release, and activity of endogenous mediators of inflammation, histamine, liposomal enzymes, including prostaglandins, kinins, and complement expression. Also modifies the body’s immune response.

Brand(s): Dexona

Manufacturer: Zydus

International name:
dexamethasone15mg Dexone

Group affiliation:
glucocorticosteroid

Description of the active substance (INN):
dexamethasone

Dosage form:
tablets

Structure and Composition:

1 tablet contains 0.5 mg dexamethasone; contour package — 10 pcs.

Indications for use of the drug Dexon:

Tablets: rheumatoid arthritis, allergies, asthma, dermatological diseases, acute ulcerative colitis, rheumatic fever, disseminated lupus erythematosus, nephrotic syndrome, malignant disease.

Contraindications:

Tablets injection: systemic fungal and viral infections.

 

Indications for use:
-Systemic connective tissue diseases (The medicine is used to treat lupus, scleroderma, periarteritis nodosa, dermatomyositis, rheumatoid arthritis).

 

-Rheumatic fever, acute rheumatic heart disease. The medicine is used to treat Bronchial asthma, asthmatic status.

 

-Acute and chronic allergic diseases: allergic reactions to drugs and foods, serum sickness, urticaria. The medicine is used to treat allergic rhinitis, angioedema, drug rash, hay fever.

 

-Acute and chronic inflammatory joint diseases, gout and psoriatic arthritis, osteoarthritis (including post-traumatic). The medicine is used to treat arthritis, frozen shoulder, ankylosing spondylitis (Bechterew’s disease). The medicine is used to treat juvenile arthritis, Still’s syndrome in adults, bursitis. The medicine is used to treat tenosynovitis nonspecific, synovitis and epicondylitis .

 

-Skin diseases: pemphigus, psoriasis, eczema. The medicine is used to treat atopic dermatitis, atopic dermatitis, contact dermatitis (with the defeat of the large surface of the skin). The medicine is used to treat drug reaction, seborrheic dermatitis, exfoliative dermatitis, toxic epidermal necrolysis (Lyell’s syndrome). The medicine is used to treat bullous dermatitis herpetiformis, malignant exudative erythema (syndrome Stevens-Johnson syndrome).

 

-Allergic eye diseases: allergic corneal ulcers, allergic forms of conjunctivitis. Inflammatory eye diseases: sympathetic ophthalmia, heavy sluggish front and posterior uveitis, optic neuritis.

 

— Primary or secondary adrenocortical insufficiency (including the state after the removal of the adrenal glands).

 

— Congenital adrenal hyperplasia.

 

-Cerebral edema after prior parenteral use.

 

-Kidney disease of autoimmune origin (including acute glomerulonephritis); nephrotic syndrome. Subacute thyroiditis. Diseases of the blood — agranulocytosis, panmielopatiya; The medicine is used to treat autoimmune hemolytic anemia, acute myeloid leukemia and lymphomaŃŽ The medicine is used to treat Hodgkin’s disease, thrombocytopenic purpura, secondary thrombocytopenia in adults, erythroblastopenia (erythrocytic anemia). The medicine is used to treat congenital (erythroid) hypoplastic anemia. Lung disease: acute alveolitis, pulmonary fibrosis, sarcoidosis II-III art.

 

-Tuberculous meningitis, tuberculosis, aspiration pneumonia (in combination with a specific chemotherapy). The medicine is used to treat Berylliosis, Loffler’s syndrome (not amenable to others. Therapy). The medicine is used to treat Lung cancer (in combination with cytostatics). Multiple sclerosis. Gastrointestinal diseases: ulcerative colitis, Crohn’s disease, local enteritis.

 

-Hepatitis. The medicine is used to treat Prevention of graft rejection. The medicine is used to treat Hypercalcemia on the background of cancer, nausea and vomiting during cytostatic therapy. Multiple myeloma. The medicine is used: Conduct tests in the differential diagnosis of hyperplasia (hyperfunction) and tumors of the adrenal cortex.

 

Taken with caution:
Parasitic and infectious diseases of viral, fungal or bacterial origin — herpes simplex, herpes zoster (viremicheskaya phase). Pay attention to: chicken pox, measles; amoebiasis, strongyloidiasis (or suspected); Pay attention to: systemic mycosis, active and latent tuberculosis. Application for serious infectious diseases is admissible only against the background of specific therapy. Pay attention to: Pre- and post-vaccination period (8 weeks before and 2 weeks after vaccination), lymphadenitis after BCG vaccination. Immunodeficiency states (including AIDS or HIV infection).

Pay attention to: Diseases of the digestive tract — stomach ulcer and 12 duodenal ulcer, esophagitis, gastritis, acute or latent peptic ulcer, recently established intestinal anastomosis, ulcerative colitis with the threat of perforation or abscess formation, diverticulitis.

Pay attention to: Diseases of the cardiovascular system, including recent myocardial infarction (in patients with acute and subacute myocardial infarction may spread necrosis, slowing the formation of scar tissue and therefore — rupture of the heart muscle), decompensated chronic heart failure, hypertension, hyperlipidemia.

Pay attention to: Endocrine diseases — diabetes mellitus (including breach of tolerance to carbohydrates), hyperthyroidism, hypothyroidism, Cushing’s disease.

Pay attention to: Severe chronic renal and / or hepatic insufficiency, nefrourolitiaz. Hypoalbuminemia and conditions that predispose to its occurrence.

Pay attention to: Systemic osteoporosis, myasthenia gravis, acute psychosis, obesity (III-IV cent.), Polio (except bulbar form of encephalitis) and open-angle-closure glaucoma, lactation.

 

Side effects:

The frequency and severity of side effects depend on the duration of application, size of the dosage used and the possibility of compliance circadian rhythm of destination.

Part of the endocrine system: reduction of glucose tolerance, «steroid» diabetes or a manifestation of latent diabetes mellitus. There may be some side effects: adrenal suppression, Cushing’s syndrome (moon face, obesity, pituitary type, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, myasthenia gravis, striae). There may be some side effects: delayed sexual development in children. From the digestive system: There may be some side effects: nausea, vomiting, pancreatitis, «steroid» stomach ulcers and 12 duodenal ulcer. There may be some side effects: erosive esophagitis, bleeding and perforation of the gastrointestinal tract, increased or decreased appetite, flatulence, hiccups. In rare cases there may be some side effects: increased activity of «liver» transaminases and alkaline phosphatase. From the CCC: arrhythmia, bradycardia (up to heart failure); development (in predisposed patients) or increased severity of CHF, Other side effects: ECG changes typical of hypokalemia, increased blood pressure, hypercoagulation, thrombosis. Patients with acute and subacute myocardial infarction — the spread necrosis, slowing the formation of scar tissue, which can lead to rupture of the heart muscle. From the nervous system: delirium, disorientation, euphoria. Other side effects: hallucinations, manic-depressive psychosis, depression. As well as: paranoia, increased intracranial pressure, nervousness or anxiety, insomnia. Rarely can be: dizziness, vertigo, pseudotumor cerebellum, headache, convulsions. From the senses: posterior subcapsular cataracts, increased intraocular pressure with possible damage to the optic nerve, the propensity to develop secondary bacterial, fungal or viral eye infections, trophic changes of the cornea. As well as: exophthalmos. On the part of metabolism: increased excretion of Ca2 +, hypocalcemia, increased body weight, negative nitrogen balance (increased breakdown of proteins), increased sweating. The resulting ISS activity — fluid retention and Na + (peripheral edema), hypernatremia, gipokaliemichesky syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue). On the part of the musculoskeletal system: slowing growth and ossification in children (premature closure of epiphyseal growth zones), osteoporosis (very rare — pathological fractures, aseptic necrosis of the humeral head and femur). As well as: rupture of tendons of muscles, «steroid» myopathy, reduced muscle mass (atrophy). For the skin and mucous membranes: delayed wound healing, petechiae, ecchymosis, skin thinning, atrophy of skin and subcutaneous tissue, hyper- or hypopigmentation. Rarely can be: steroid acne, striae, susceptibility to the development of pyoderma and candidiasis. Allergic reactions: generalized (skin rash, itching skin, anaphylactic shock), local allergic reaction. Other: the development or exacerbation of infection (the appearance of this side effect contribute jointly used immunosuppressive drugs and vaccinations), Pyuria, the syndrome of «cancellation»

 

Overdose.

 

Symptoms: may increase the side effects described. In this case, the dose should be reduced. Treatment: symptomatic.

 

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