Drug Information: Indications, Side Effects, Warnings
Description of the active substance:
Generic Biaxin (Clarithromycin)
The selling Generic Biaxin (Clarithromycin) is by prescription
Granules for suspension for oral administration, capsules, lyophilisate for solution for infusion, powder for oral suspension, coated tablets.
A semisynthetic macrolide antibiotic with a wide spectrum of action. Violates the protein synthesis of microorganisms. Acts on the extra- and intracellular pathogens located. Active against: Staphylococcus spp., Streptococcus agalactiae (Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae), Haemophilus influenzae (Haemophilus parainfluenzae), Haemophilus ducreyi, Neisseria gonorrhoeae, Neisseria meningitidis, Listeria monocytogenes, Legionella pneumophila, Mycoplasma pneumoniae, Helicobacter pylori (Campylobacter ), Campylobacter jejuni, Chlamydia pneumoniae, Chlamydia trachomatis, Moraxella catarrhalis, Propionibacterium acne, Mycobacterium avium, Mycobacterium leprae, Mycobacterium marinom, Staphylococcus aureus, Ureaplasma urealyticum, Toxoplasma gondii, Corynebacterium spp., Pasteurella multocida Some anaerobes (Eubacter spp., Peptococcus spp., Propionibacterium spp., Clostridium perfringens, Bacteroides melaninogenicus), is less active against Micobacterium tuberculosis.
Bacterial infections caused by susceptible organisms: upper respiratory tract infection (laryngitis, pharyngitis, tonsillitis, sinusitis), lower respiratory tract infections (bronchitis, pneumonia), skin and soft tissue (folliculitis, furunculosis, impetigo, wound infection), otitis media; peptic ulcer and 12 duodenal ulcer, mycobacteriosis, chlamydia.
Hypersensitivity, porphyria, pregnancy, lactation, concomitant use of cisapride, pimozide, terfenadine. With caution. Kidney and / or liver failure.
From the nervous system: headache, dizziness, anxiety, fear, insomnia; rarely — disorientation, hallucinations, psychosis, depersonalization, confusion. From the digestive system: nausea, vomiting, gastralgia, diarrhea, stomatitis, increased activity of «liver» transaminases, cholestatic jaundice, rarely — pseudomembranous enterocolitis. From the senses: tinnitus, changes in taste; in rare cases — hearing loss, after drug withdrawal. From the side of hematopoiesis and hemostasis system: rarely — thrombocytopenia (unusual bleeding, hemorrhage). Allergic reactions: skin rash, itching, malignant exudative erythema multiforme (Stevens-Johnson syndrome), anaphylactoid reactions. Other: the development of resistance. Overdose. Symptoms: impaired function of the gastrointestinal tract, headache, confusion. The treatment: gastric lavage, symptomatic therapy.
Dosage and administration:
Inside, adults and children over 12 years — 250-500 mg 2 times a day. Duration of treatment — 6-14 days. In severe infections, or in the case of difficulty of oral administration in the form prescribed in / injection at a dose of 500 mg / day for 2-5 days, with further transfer to oral 500 mg / day. The total duration of treatment is 10 days. In the treatment of infections caused by Mycobacterium avium, sinusitis and severe infections (including those caused by Haemophilus influenzae) administered by mouth, 0.5-1 g of 2 times a day (maximum — 2 g). Duration of treatment — 6 months or more. Babies administered as a suspension in a dose of 7.5 mg / kg every 12 hours. The maximum daily dose — 500 mg. The duration of the treatment — 7-10 days. Generic Biaxin (Clarithromycin) you can buy through the Internet, it will cost you cheap.
In the presence of chronic liver disease should be carried out regular monitoring of serum enzymes. Be wary appointed of drugs metabolized by the liver (recommended measure their concentration in the blood). In the case of co-administration with warfarin or other. Indirect anticoagulants is necessary to monitor the prothrombin time. Heart diseases in history not recommended simultaneous with terfenadine, cisapride, astemizole.
Not allowed simultaneous use with cisapride, pimozide, terfenadine. When concomitantly increases the blood concentration of drugs metabolized in the liver by cytochrome P450, — indirect anticoagulants, carbamazepine, theophylline, astemizole, cisapride, terfenadine (2-3 times), triazolam, midazolam, cyclosporine, disopyramide, phenytoin, rifabutin , lovastatin, digoxin, ergot alkaloids, et al. Perhaps the development of cross-resistance between clarithromycin, clindamycin and lincomycin.
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