Amoxil (Amoxicillin)

Drug Information: Indications, Side Effects, Warnings

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Antibiotic, penicillin semisynthetic

 

Description of the active substance :

Amoxicillin.

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Dosage form (250/500mg):

Granules for oral suspension, capsule, powder for oral drops [children] powder for solution for intravenous and intramuscular administration, a powder for suspension.

Pharmacological action:

Semisynthetic penicillin has a bactericidal effect, has a wide spectrum of action. Penalized peptidoglycan synthesis (reference polymer cell wall) between the division and growth, causing bacteria lysis. It is active against aerobic gram-positive microorganisms: Staphylococcus spp. (Except for strains producing penicillinase), Streptococcus spp. and aerobic gram-negative organisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. Strains producing penicillinase, resistant to the action of amoxicillin.

Indications:

Bacterial infections caused by susceptible pathogens: respiratory infections (bronchitis, pneumonia) and otolaryngology (sinusitis, pharyngitis, tonsillitis, acute otitis media), urogenital system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis), abdominal infection (peritonitis, cholangitis, cholecystitis), infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses), leptospirosis, listeriosis, Lyme disease (borreliosis), gastrointestinal tract (dysentery, salmonellosis, Salmonella carrier) meningitis, endocarditis (prophylaxis) sepsis.

Contraindications:

Hypersensitivity (including to other penicillins, cephalosporins, carbapenems). With caution. Polyvalent hypersensitivity to xenobiotics, infectious mononucleosis, a history of gastrointestinal disease (especially colitis associated with the use of antibiotics), kidney failure, pregnancy, lactation.

Side effects:

Allergic reactions: possible urticaria, flushing of the skin, erythematous rash, angioedema, rhinitis, conjunctivitis; rarely — fever, arthralgia, eosinophilia, exfoliative dermatitis, erythema multiforme exudative (including Stevens-Johnson syndrome); reactions similar to serum sickness; in rare cases — anaphylactic shock. From the digestive system: goiter, change in taste, nausea, vomiting, diarrhea, stomatitis, glossitis, a moderate increase in activity of «liver» transaminases, rarely — pseudomembranous enterocolitis, the nervous system: agitation, anxiety, insomnia, ataxia, confusion, changes in behavior, depression, peripheral neuropathy, headache, dizziness, epileptic reaction. Laboratory findings: leukopenia, neutropenia, thrombocytopenic purpura, anemia. Other: shortness of breath, tachycardia, interstitial nephritis, vaginal candidiasis, superinfection (especially in patients with chronic diseases or low resistance of the organism) Overdose. Symptoms: nausea, vomiting, diarrhea, disruption of water and electrolyte balance (as a consequence of vomiting and diarrhea). Treatment: gastric lavage, activated charcoal, saline laxatives, drugs for maintaining water and electrolyte balance; hemodialysis.

Dosage and administration:

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Inside, before or after a meal, the tablet may be swallowed whole or divided into parts chew with a glass of water or dissolve in water to form a syrup (20 ml) and the suspension (100 ml). Adults and children over 10 years (weighing over 40 kg) prescribed 0.5 g 3 times a day; in severe infections — 0.75-1 g 3 times a day. Babies prescribed as a suspension: the age of 5-10 years — 0.25 g; 2-5 years — 0.125 g; under 2 years — 20 mg / kg, 3 times a day; in severe infections — 60 mg / kg 3 times a day. In premature infants and reduce the dose and / or increase the interval between doses. The course of treatment — 5-12 days. In acute uncomplicated gonorrhea appoint 3 g single dose; in the treatment of women recommended to repeat this dose reception. In acute infectious diseases gastrointestinal tract (paratyphoid fever, typhoid fever), and biliary tract, gynecological infectious diseases of adults — 1.5-2 g 3 times a day or 1-1.5 g 4 times a day. When leptospirosis adults — 0.5-0.75 g 4 times a day for 6-12 days. When salmonellonositelstve adults — 1.5-2 g 3 times a day for 2-4 weeks. For the prevention of endocarditis with small surgical interventions for adults — 3-4 g for 1 h prior to the procedure. If necessary, repeat dose administered over 8-9 hours. In children, the dose is reduced by 2 times. In patients with impaired renal function in QA 15-40 ml / min interval between doses increased to 12 hours; with CC less than 10 ml / min the dose is reduced by 15-50%; in anuria — the maximum dose of 2 g / day. You can buy Generic Amoxil through the Internet, it will cost you cheap. For adult use Generic Amoxil 250 mg.

Special instructions:

The doctor will write you a prescription Generic Amoxil during infection. In exchange treatment is necessary to monitor the state functions of blood, liver and kidneys. Perhaps the development of superinfection due to growth insensitive to it microflora, which requires a corresponding change in antibiotic therapy. In appointing the patients with sepsis may develop bacteriolysis reaction (Jarisch-Herxheimer) (rare). In patients with increased sensitivity to penicillin, may cross with other allergic reactions. Beta-lactam antibiotics. In the treatment of mild diarrhea at the background of a course of treatment should be avoided antidiarrhoeal drugs that reduce intestinal motility; You can use kaolin or attapulgit-containing antidiarrhoeal drugs. Patients with severe diarrhea should consult a doctor. Treatment continues for sure 48-72 hours after the disappearance of clinical signs of disease. With simultaneous use of oral contraceptives and estrogen -containing amoxicillin should be possible to use the other. Or additional methods of contraception.

Interaction:

Pharmaceutical incompatible with aminoglycosides (to avoid mutual inactivation can not be mixed). Antacids, glucosamine, laxatives, drugs, food, aminoglycosides slow down and reduce absorption; Ascorbic acid enhances the absorption. Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) — antagonistic. Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); estrogensoderzhaschih reduces the effectiveness of oral contraceptives; PM, in the process of metabolism that produce PABA, ethinyl estradiol — the risk of bleeding «breakthrough.» Amoxicillin reduces clearance and increases toxicity of methotrexate; enhances the absorption of digoxin. Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, NSAIDs, and others. Drugs that block tubular secretion, increase the concentration of amoxicillin in the blood. Allopurinol increases the risk of skin rash.

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