Meclizine is used as an antiemetic, antihistamine, anti-allergic drug.
Therapeutic agent of Meclizines
The nosological classification (ICD-10)
H81.0 MĂ©niĂ¨re’s Disease
H81.9 Violation of vestibular function, unspecified
L20 Atopic dermatitis
R11 Nausea and vomiting
T78.4 Allergy, unspecified
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
Pharmacology of Meclizine
Mode of action — antiemetic, antihistamine, anti-allergic.
Blocks of H1-histamine receptors and reduces the vasodilator effect of histamine spasmogenic. It has weak activity.
Application of Meclizine
Nausea, vomiting and dizziness (including when kinetoses, Meniere’s syndrome, labyrinth and vestibular disorders, vertigo); immediate type allergic reactions (including skin diseases accompanied by itching).
Contraindications of Meclizine
Hypersensitivity, children under 12 years of age (safety and efficacy of the children are not identified).
Restrictions apply to:
Bronchial asthma, glaucoma, an enlarged prostate, pregnancy.
Side effects of Meclizine
From the nervous system: fatigue, drowsiness, children — sometimes irritability, rarely — blurred vision.
From the digestive tract: dry mouth, vomiting.
Overdose of Meclizine
Symptoms in adults — CNS depression, drowsiness, coma, convulsions; in elderly patients — hypotension; children — CNS stimulation (hallucinations, sleep disorders, convulsions).
Treatment: induction vomiting (if from the moment of the reception was not more than 1 hour), gastric lavage, the appointment of activated carbon; symptomatic and supportive therapy; with hypotension — introduction of vasopressor agents (other than epinephrine); to mitigate the effects of anticholinergic — physostigmine; with a view to treat seizures Diazepam (w / w).
Dosage of Meclizine
Inside; adults and children over 12 years:
for the prophylaxis and symptomatic treatment of nausea, vomiting and dizziness:
25-100 mg / day in divided doses. If motion sickness — once 25-50 mg 1 hour before traveling; if necessary — again every 24 hours;
nausea and vomiting during pregnancy — 25-50 mg / day;
and labyrinth disorders vestibular disorders — 25-100 mg / day;
nausea and vomiting with radiation therapy — 50 mg for 2-12 hours prior to irradiation.
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