Exelon (Rivastigimine)

Drug Information: Indications, Side Effects, Warnings

Category:  Alzheimer’s and Parkinson’s

Generic Exelon is used for treating mild to moderate dementia (eg, impairment of memory or judgement, abstract thinking, changes in personality) in patients with Alzheimer disease or Parkinson disease.order tablet Exelon 6mg

Nosological classification (ICD-10):

— F00 Dementia in Alzheimer’s disease (G30 +)

Active ingredient: rivastigmine 9 mg, 18 mg, 27 mg, exelon 1.5 mg capsules.

auxiliary substances: D, L-α-tocopherol — 0.03 / 0.06 / 0.09 mg; poly (-butilmetakrilat, -metilmetakrilat) — 06/12/18 mg; acrylic acid copolymer — 14.97 / 29.94 / 44.91 mg

adhesive layer: silicone copolymer — 14.84 / 29.67 / 44.505 mg; dimethicone (silicone oil 12,5 cSt) — 0,15 / 0,3 / 0,45 mg; D, L-α-tocopherol — 0.015 / 0.03 / 0.045 mg

polymeric envelope: PET substrate, 23 microns — 5/10/15 cm2;
PET protective fluoropolymer coating 75 microns — 10.13 / 20.25 / 29.16 cm2

Pharmacological action is anticholinesterase.

Initial dose:
Treatment should start by using TTS Ekselon® 4.6 mg / day 1 time per day.

Maintenance dose:
After 4 weeks of treatment, at least, with good tolerability, the dose may be increased by the use of TTS Ekselon® 9.5 mg / day.

Dose escalation:

 

For long-term treatment in the presence of the therapeutic efficacy of the patient is recommended to use TTS Ekselon® 9.5 mg / day.

Doctor may increase the dose if tolerated the drug to patients. This will allow Dost additional therapeutic effect. The dose of drug may be increased up to 13.3 mg / day in patients.

 

Description of the dosage form:

Capsules 1.5 mg: opaque, yellow, size №2, marked on the body «EXELON 1,5 mg» red ink radially.

Capsules 3 mg: opaque, orange color, size №2, marked on the body «EXELON 3 mg» red ink radially.

Capsules 4.5 mg: opaque, red, size №2, marked on the body «EXELON 4,5 mg» white ink radially.

6 mg capsules: opaque, with red cap and orange body size №2, marked on the body «EXELON 6 mg» red ink radially.

Capsule contents: powder from nearly white to pale yellow color.

Oral solution: clear yellow solution.

 

Pharmacokinetics:

absorption:

Rivastigmine is rapidly and completely absorbed.
Cmax in plasma attained after approximately 1 hour.
After taking a dose of 3 mg, absolute bioavailability of approximately is 36%.

 

Distribution:

Rivastigmine binds to plasma proteins to a lesser degree (approximately 40%). Easily penetrates through the BBB. Apparent VSS is 1.8-2.7 l / kg.

 

Excretion:

— excreted by the kidneys as metabolites

— Is not found in unchanged form in the urine.
After 24 hours after taking, more than 90% of the dose excreted. Less than 1% of the dose is excreted in the feces.

 

Indications drug Ekselon®:

— mild to moderate dementia of Alzheimer’s type (Alzheimer’s disease, including probable);

— mild to moderate dementia in Parkinson’s disease.

 

Contraindications:

— hypersensitivity to rivastigmine, other carbamate derivatives or other ingredients in the composition of the drug;

— patients with severely impaired hepatic function (since the application is not known);

— children (use of the drug in children has not been studied, therefore, to appoint not recommended).

Precautions:

— sick sinus syndrome or conduction defects — sinoatrial and AV block (and other nicotinic agents);

— urinary tract obstruction and convulsions (cholinergic stimulation can increase the secretion of hydrochloric acid in the stomach, lead to increased urinary obstruction, and exacerbation of seizures);

— asthma or obstructive airways diseases in history (as well as other cholinomimetics);

 

Side effects:

Most common adverse reactions from the gastrointestinal tract: nausea (38%), vomiting (23%), mainly in the period of increased dose. According to clinical studies adverse reactions on the part of the digestive system and weight loss were more common in women.

Urinary tract infection is very rare

CNS side effects:

 

Agitation
Common: Confusion
often Insomnia
sometimes Depression
sometimes Hallucinations
Very rare Dizziness
Very rare Headache
often Drowsiness
often Tremor
often Fainting
Sometimes Seizures

Where to buy?

Buy Generic Exelon (Rivastigimine) you can at the pharmacy.

Can I buy online?

 

You can buy Generic Exelon (Rivastigimine) online delivery through the post office.

How to buy Generic Exelon (Rivastigimine) cheaper?

You can buy the drug cheaper, using a coupon or discount cards. Sometimes there are promotions and sales.

 

Prices for 28-180 capsules of generic rivastigmine 1.5-6 mg

Buy Exelon No Prescription in pharmacy online «Together Rx Access».